Sympathetic Control

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Known as the "fight or flight" mechanism the sympathetic nervous system originates in the thoracic and lumbar regions of the spinal cord. Most postsynaptic sympathetic nerve endings release adrenaline or norepinephrine. Sympathetic stimulation of the heart has two effects: (1) it increases the heart rate (250 bpm with maximal stimulation); and (2) it increases the force of contraction which decreases the duration of systolic contraction and allows more time for filling during diastole. The innervation of the small arteries and arterioles allows sympathetic stimulation to increase the resistance thereby changing the rate of blood flow through the tissues. The innervation of the large vessels (particularly of the veins) makes it possible for sympathetic stimulation to change the volume of these vessels and alter the volume of the peripheral circulatory system. This can translocate blood into the heart, thus playing a major role in the regulation of cardiovascular function.


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