Formation of the Interatrial Septum

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Theinteratrial septum forms between the 27th and the 37th day of development and occurs in conjunction with the development of the ventricular septum as well as the separation of the truncus arteriosus. The  sinus venosus remains paired the longest during the heart development. By the end of the fourth week of development, it consists of a small transverse portion and the right and left sinus horns. Each horn receives blood from three important veins : the umbilical, the common or cardinal vein and the vitelline veins. Eventually, the left horn of the sinus venosus becomes partially obliterated leaving behind the oblique vein of the left atrium and the coronary sinus.

 Initially, the sinus venosus receives blood from the yolk sac via the vitelline veins as well as from the chorionic villi via the umbilical veins. Blood is also received from the anterior and posterior cardinal veins, which drain the cranial region of the embryo and body.

 The junction between the right side of the sinus venosus and the atrium folds inward to form the right venous or sinus valve . In the embryo, this valve is large and directs blood from the inferior vena cava across the interatrial septum. It also extends inferiorly to cover the coronary sinus.


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